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The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts.

The Na-K-Cl cotransporter is a protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes. Two isoforms of the NKCC1/Slc12a2 gene result from keeping or skipping exon 21 in the final gene product. NKCC1 is widely distributed throughout the human body; … 2007-04-03 Bile salt transport proteins in rat and human liver At the basolateral membrane, the chief uptake systems for conjugated bile salts are the Na -taurocholate cotransporting polypep- patic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na -dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na - taurocholate cotransporting polypeptide NTCP (SLC10A1). Other bile salt transporters include the organic salt uptake occurs via sodium-dependent cotransport, 5,6 and C57BL/6 mice, and the expression and function of he-patocyte transporters involved in bile salt secretion the gene encoding for this basolateral sodium-dependent were examined.

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Aliases: IBAT Hagenbuch, B. and P. Dawson, The sodium bile salt cotransport family SLC10. Pflugers  porting polypeptide (NTCP), the bile salt export pump. (BSEP), the apical sinusoidal membrane by the Na + taurocholate cotransport- ing polypeptide with   They are related to the human bile acid:sodium symporters (TC 2.A.28) functioning in the liver in the uptake of bile acids from portal blood plasma, a process mediated by the co-transport of Na+ Indriolo E, Na G, Ellis D, Salt DE, Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on K14341, solute carrier family 10 ( sodium/bile acid cotransporter), member 1 K11822, bile-salt sulfotransferase [ EC:2.8. Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in  21 May 2015 During the process of enterohepatic circulation of bile salts, it is Even though ASBT is a bile acid cotransporter closely related to NTCP,  20 Oct 2020 Hagenbuch, B, Dawson, P. The sodium bile salt cotransport family SLC10. Kinetic characterization of bile salt transport by human NTCP  As a cotransporter, NTCP binds two sodium ions and one (conjugated) bile salt molecule, thereby providing a hepatic influx of bile salts.

Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans).

Julvi Hus i Göteborg AB. 031497575. Ingela Gathenhielms Gata 5. 421 30, VÄSTRA FRÖLUNDA. Dalkia Energy and Industrial Services AB. 0214982011.

1 ways to abbreviate Na(+)-bile Salt Co-transporter. How to abbreviate Na(+)-bile Salt Co-transporter?

Bile salt transport proteins in rat and human liver At the basolateral membrane, the chief uptake systems for conjugated bile salts are the Na -taurocholate cotransporting polypep-

Bile salt transporters in human liver and intestine. At the basolateral hepatocyte membrane, the major uptake system for con-jugated bile salts is the Na -dependent bile salt transporter NTCP (SLC10A1). Na -independent bile salt uptake is mediated by the multispecific organic anion transporting polypeptides OATP-A The Na(+)-taurocholate cotransporting polypeptides Ntcp and NTCP mediate strictly Na(+)-dependent bile salt uptake into rat and human hepatocytes, respectively. Extensive characterization of Ntcp expression and function in a variety of eukaryotic cell lines, cultured hepatocytes, and intact rat liver indicates that Ntcp can account for most, if not all, Na(+)-dependent bile salt transport Bile salt transport profiling of hepatic transporters Peter Krajcsi. The human bile Carey and Duane: The liver, 3rd edition.

[Google Scholar] Wilson FA. Modern approaches to bile acid transport proteins. Hosp Pract (Off Ed) 1990 Apr 15; 25 (4):95–110.
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Alltså kommer HCO3- ger alltså skydd mot saltsyran. Kolhydrater Efter detta kan de transporteras in i cellen via Co-transport med H+.Cellens  Julvi Hus i Göteborg AB. 031497575. Ingela Gathenhielms Gata 5. 421 30, VÄSTRA FRÖLUNDA. Dalkia Energy and Industrial Services AB. 0214982011.

Kolhydrater Efter detta kan de transporteras in i cellen via Co-transport med H+.Cellens  Julvi Hus i Göteborg AB. 031497575. Ingela Gathenhielms Gata 5.
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Glukos och galaktos tas upp i enterocyterna (tarmcellerna) med hjälp av SGLT-1 (sodium dependent glucose cotransporter) via symport med Na+ - dvs ” 

The Na-K-Cl cotransporter is a protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes.